We investigate the moment Hilary Clinton establishes her global profile.

Risking political controversy and international condemnation, Hilary Clinton delivers an electrifying speech that reverberates around the world. We hear from eyewitnesses as she sets out a compelling and devastating case that women's rights are human rights. We explore the implications of the speech that established her as a globally important political figure - both at the White House and internationally.

Malala Yousafzai made global headlines when she was shot in the head for speaking out against Taliban militants. Barely a year later, she addressed the United Nations Youth Takeover and gave an inspiring speech in support of education for women, girls and children. We hear from another Youth Ambassador who watched the speech and explore the impact of this incredible young woman’s speech.

The birth of the smart phone signalled a revolution in technology. A black rectangle on a big screen – that was the first glimpse the world had of the iPhone as Steve Jobs delivered a key note speech like no other, blowing his competition out of the water. We discover the reactions of the public, press and people in the industry to this game-changing piece of technology, and the introduction of an ultimate digital device.

An all-American mum dropped a bombshell on the Republican National Congress in 1992. Mary Fisher stood before the thousands of people and revealed she had HIV. At the time sufferers were rebuked, ostracised and blamed for the epidemic. And so it was that Mary Fisher smashed the message through to the political establishment that the epidemic was facing all of America.

As America trails the USSR in the space race, President John F Kennedy makes an audacious promise that would lead to one of humankind's greatest achievements. This programme explores how one big idea to boost morale, and spend billions of dollars, can put a man on the moon.

JFK sets out his plans – but would you back this man’s out-of-this-world ideas? Our experts – and a Nobel prize-winning scientist who witnessed the speech – give their blunt and revealing opinions on this ambitious political adventure.

In these speeches, two world leaders managed the unthinkable – a thaw in the hostile relationships between East and West after decades of Cold War. We explore the speeches of Mikhail Gorbachev and Ronald Reagan and how they led to the fall of the Berlin Wall and the end of the USSR.